范登伯格估计,这项技术有望在四五年之内达到做人类临床试验的条件。他说,这一方法将最适合某些肌肉受损的人,而不是身患某种疾病、导致肌肉总体萎缩的人。
Early trials could target drooping eyelids, for example, by injecting the stem cells into the muscle around the eye. The hope would be for the healthy stem cells to migrate to the wounded tissue and regenerate it.
早期试验可能会以下垂的眼睑为目标,比如说向眼部周围的肌肉注入干细胞,希望健康干细胞能够进入受损组织,使之重新生长。
Another challenge to using regenerated muscle for therapeutic purposes is the size of the tissue that can be regenerated, experts say. For instance, the mouse calf muscle generated by the team currently is about 20 millimeters long and 4 to 5 millimeters wide, a fraction of the human calf muscle.
专家说,使用再生肌肉用于治疗目的另一重挑战在于能够再生的组织的大小。比如团队目前培育的老鼠腓肠肌约为20毫米长,4到5毫米宽,只占人类腓肠肌的很小一部分。
Because muscle tissue is very dense, it's difficult to get enough oxygen and blood flow to the muscle on the inside of the tissue, Dr. Bursac says. He and other researchers, such as those at Washington University in St. Louis, are trying to create channels in muscle tissue that can deliver the nutrients the muscle needs.
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