必治妥施贵宝公司(Bristol-Myers Squibb)的拉斐尔·克莱因 (Raphael Clyne)博士在哥伦比亚大学当教授期间是这项研究的负责人之一,他表示,研究团队拿老鼠做测试时用过膏剂和片剂,并且打算进行膏剂的人体测试。
So far, he considered ruxolitinib “an expensive therapy that’s probably effective based on the small number of patients that we’ve treated, and it’s likely to have a reasonable safety profile. But there’s no way that I can endorse it fully unless we do larger trial.”
他认为鲁索利替尼迄今为止还是“一种价格高昂的治疗手段。就我们治疗的为数不多的患者而言,它或许是有效的,在安全性方面的表现似乎也说得过去。但除非进行更大规模的测试,否则我绝不会完全认可这种疗法”。
The team also plans to test on people another JAK inhibitor, tofacitinib, which is approved for rheumatoid arthritis and grew hair on mice. In June, Dr. Brett King, a dermatologist at Yale, reported that tofacitinib caused full hair growth and no negative effects for a man with alopecia universalis, a variant involving almost total hair loss.
研究团队还打算对另外一种JAK抑制剂——托法替尼(Tofacitinib)——进行人体测试。这是一种获批治疗类风湿关节炎的药物,能让老鼠长出毛发。今年6月,耶鲁大学(Yale)皮肤病专家布莱特·金(Brett King)博士宣称,托法替尼(Tofacitinib)能促进男性普秃患者的毛发生长,且没有任何副作用。普秃是一种几乎可以造成全身毛发全部脱落的疾病。
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