'Genetic variation in KLOTHO could help us predict brain health and find ways to protect people from the devastating diseases that happen to us as we grow old, like Alzheimer's and other dementias.'
“klotho基因变体能够帮我们预测大脑健康状况,为保护人们在衰老过程中免遭如阿茨海默症或痴呆等疾病的威胁寻找方法。”
About one in five people carry a single copy of the variant, known as KL-VS, that boosts levels of the protein and is associated with longer lifespan and improved heart and kidney function.
大约每五个人中有一个人会携带这种叫做KL-VS的基因变体副本,它能提高蛋白质水平、使人更长寿、提升心脏和肾脏功能。
A small minority, 3% of the population, has two copies, which is linked to a shorter lifespan.
极少数人群,大约占总人口的3%,携带有两个该基因副本,这会使人更短寿。
In the new study scientists scanned the brains of 422 men and women aged 53 and over who were also tested for the KLOTHO gene.
在一项最新研究中,科学家们扫描了422个年龄在53岁以上的、被检测出携带klotho基因的男性和女性。
They found that participants with a single copy of the gene variant also had a larger brain region known as the right dorsolateral prefrontal cortex (rDLPFC), which is especially susceptible to shrinkage with age.
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