Telling MPs that both sides have had to make compromises, May added: "The backstop is essential. Without a backstop, there will be no agreement."
She added that under the deal, for the first time in 40 years Britain will be able to open up new trade deals around the world.
Insisting what was agreed in Brussels was the best deal available, May said no one knows what would happen if it does not pass.
With so many MPs from May's own Conservative Party as well as opposition MPs saying they will vote against her deal, political commentators are already predicting a possible defeat for the Brexit deal next month.
But May remained determined to see the deal through. "The British people want MPs to get on with a deal and allow the country to come together," she said.
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