研究发现,该气雾型疫苗在肺中产生的埃博拉免疫细胞,远多于血液和脾。“肺里的这些细胞充当着第一道保护屏障,梅耶尔说。“在感染的地方阻击病毒是最好的。
Four of the rhesus macaques used in the research were given one dose of the aerosol vaccine;four were given two doses; and two were given the vaccine in a liquid form. Two monkeyswere not vaccinated, serving as controls.
在研究使用的恒河猴中,四只服用了一剂该气雾型疫苗,四只服用了两剂,两只服用了液态形式的该疫苗。还有两只未接种疫苗,充当着控制组的研究对象。
Four weeks after their treatments, all 12 monkeys were injected with 1,000 times the fataldose of the Ebola virus. A little over a week later, the two unvaccinated monkeys succumbed tothe disease and were euthanized, but the vaccinated monkeys stayed healthy. At the end of thestudy, the researchers euthanized the surviving monkeys, examined their blood and tissues,and found no traces of the Ebola virus.
四周后,12只猴子体内全被注入了1000倍于致死剂量的埃博拉病毒。一周多一点后,那两只未接种疫苗的猴子被该病毒感染,接受了安乐死,但接种了疫苗的猴子依然很健康。最后,研究人员对幸存下来的猴子实行了安乐死,并对它们的血液和组织进行了检查,未发现埃博拉病毒的踪迹。
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