国际英语资讯:Low-dose aspirin found to work on blood platelets, help prevent cancer: researchers_时事

国际英语资讯:Low-dose aspirin found to work on blood platelets, help prevent cancer: researchers

SAN FRANCISCO, Feb. 16 (Xinhua) -- Researchers have found that low-dose aspirin, or "baby" aspirin, may inhibit the normal function of blood platelets and reduce their ability to upregulate an "oncoprotein" called c-MYC, which plays an important role in cancer cell proliferation and survival.

The mechanism by which low-dose aspirin may have some benefits in helping cancer prevention, especially colon cancer, in addition to protection against cardiovascular disease, was the result of a study published in AJP-Cell Physiology by researchers at Oregon Health & Science University (OHSU) and Oregon State University (OSU).

国际英语资讯:Low-dose aspirin found to work on blood platelets, help prevent cancer: researchers1

"The benefit of aspirin may be due to its effect on blood cells called platelets, rather than acting directly on tumor cells," said senior author Owen McCarty, a professor in the Department of Biomedical Engineering at OHSU. "Our work suggests that the anti-cancer action of aspirin might be in part as follows: during their transit in the blood, circulating tumor cells interact with platelets, which spur tumor cell survival by activating oncoproteins such as c-MYC. The inhibition of platelets with aspirin therapy reduces this signaling between platelets and tumor cells, thus indirectly reducing tumor cell growth."

C-MYC orchestrates the expression of more than 15 percent of all genes, including those involved in cell cycles, survival, protein synthesis and cell metabolism.

However, it appears to be overexpressed in a large number of human cancers, including colon, pancreas, breast, lung and prostate cancers. "Early cancer cells live in what's actually a pretty hostile environment, where the immune system regularly attacks and attempts to eliminate them," said Craig Williams, a professor in the OSU/OHSU College of Pharmacy and co-author on the study. "Blood platelets can play a protective role for those early cancer cells and aid metastasis. Inhibition with aspirin appears to interfere with that process and c-MYC may explain part of that mechanism."