The researchers also triggered the participants' immune systems with a harmless compound from bacterial cells before taking a second blood sample.
The lonelier the person, the higher the levels of cytokine interleukin-6 after the stressful speech. This cytokine is important for healing in the short term, because it promotes inflammation — think of the redness and swelling that accompanies a healing cut. However, when cytokines react too readily, inflammation can be harmful. Chronic inflammation has been linked to coronary heart disease, arthritis, Type 2 diabetes and even suicide attempts.
Researchers have long known that chronic stress has a similar inflammation-producing, immune-disrupting effect on the body. Loneliness, in fact, may act as its own source of chronic stress, Jaremka said. Earlier research shows that close and connected relationships are necessary to help people thrive; without them, people are under a constant stressful cloud of missing this crucial social connection.
People who are lonely also tend to react more strongly to negative events in their lives, Jaremka said. If lonely people experience daily life as more stressful, it may cause chronic stress, which in turn disrupts the immune system.
Solving the problem is harder than telling lonely hearts to go out and seek more close friends, Jaremka said — it's easier said than done. But if researchers can figure out how loneliness results in poor health, they may be able to come up with treatments that disrupt the links, in essence making loneliness less of a burden, at least physically.
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