The researchers studied female mice that were exposed to mild stresses such as the smell of foxes or unfamiliar noises during the first week of pregnancy. They identified an enzyme called OGT that was present at lower levels in the placentas of stressed mice than in unstressed mice.
经研究人员鉴定有压力的小白鼠比没有压力的小白鼠胎盘内的一种称为转移酶(OGT)的这种酶含量低。
Male offspring placentas also had lower natural levels of OGT than those attached to female offspring.
男性胎盘的转移酶也比女性胎盘的转移酶含量低。
Further research showed that cutting levels of OGT triggered changes in more than 370 genes in the brains of unborn mice.
进一步研究发现转移酶含量降低引起了未出生小白鼠大脑中370个基因发生变化。
Many of these genes play a role in functions critical to neurological development, such as energy use, protein regulation and creating nerve cell connections.
这些基因对神经发育功能起到关键作用,如精神状态、蛋白质调节、造神经细胞、连接神经细胞。
Analysis of human placentas discarded after the birth of male babies showed evidence of reduced OGT levels.
分析男婴出生后的胎盘,结果表明转移酶的含量降低了。
The results suggest that OGT may protect the brain during pregnancy. Males have less of the protein to begin with, placing them at greater risk if their mothers are stressed.
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