和所有具有相关性的结果一样,值得注意的是该分析并未显示出喝咖啡与自杀风险降低之间的因果关系,这项研究中也没有任何证据显示突然大幅提高你的咖啡因摄入量可缓解抑郁症。同样值得注意的是,本研究中调查的三项研究均是群组研究,这表示这些研究是在几年的时间内,对大型组群的多个健康风险因素进行追踪,在这种研究设计中,要对多个变量进行控制会出奇的困难。统计学家并不经常采用群组研究的结果。
Having said that, the neurochemistry behind the finding makes sense. As discussed in a previous article, caffeine acts as an expert mimic of a chemical called adenosine in the brain and other parts of the body. Adenosine is a sort of checks-and-balances chemical produced by neurons as they fire throughout the day; the more adenosine is produced, the more the nervous system ratchets down activity, until we eventually fall asleep and reboot the process.
话虽如此说,但这一发现背后的神经化学分析还是有些意义的。咖啡因的作用类似于大脑和身体其他部位中存在的一种称为腺苷的化学物质。腺苷由神经元产生,起制约平衡的作用;产生的腺苷越多,神经系统的活跃性越低,直至我们最终睡去并重新焕发活力。
By mimicking adenosine, caffeine blocks receptors in the nervous system from receiving the signals to decrease energy expenditure. When that happens, levels of the brain’s homegrown neuro-stimulants—dopamine and glutamate—increase, and we experience the brain stimulating effects associated with drinking a big cup of java.
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