Detox proponents define toxins very broadly. Mark Hyman, a physician and author of six best-selling diet books, says the biggest toxic threats come from the American diet itself. 'We are eating pharmaceutical doses of sugar and flour,' which have overwhelmed the liver's ability to cope, says Dr. Hyman. He points to the overabundance of Americans with fatty liver disease, which leads to obesity, insulin resistance and other metabolic disorders.

排毒支持者对毒素的定义非常宽泛。六本最畅销饮食书籍的作者、医师马克・海曼(Mark Hyman)称，最大的毒素威胁来自美式饮食本身。海曼博士说，“我们正在进食药物剂量的糖和面粉，”这已使得肝脏的应对能力不堪重负。他指出，过多的美国人都患有脂肪肝疾病，而这将导致糖尿病、胰岛素抗性和其他一些代谢紊乱症。

He says Americans are also being assaulted by heavy metals (including mercury from large fish and old dental fillings) and endocrine-disrupting chemicals (including Bisphenol A in makeup and credit-card receipts) as well as 'spiritual toxins,' such as loneliness and hostility. But he says people reduce their exposure and enhance their ability to excrete such toxins with the right balance of foods, vitamins and minerals.

他说，美国人还正在遭受重金属（包括来自大型鱼类和老式补牙填充物中的汞）、环境内分泌干扰物（包括化妆品和信用卡收据中的双酚A）以及诸如孤独和敌意这样的“精神毒素”的侵害。但他表示，人们减少了与这些毒素的接触，并通过正确平衡饮食、维他命和矿物质来增强自身排毒的能力。

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