在研究结束时,随时可以进食的小鼠普遍都变得肥胖,并患上了代谢疾病,这印证了早期的研究结果。但相比之下,即使周末偶有放肆,那些平时每天只有9或12小时可以进食的小鼠体型保持得很好,身体也很健康。更重要的是,从随时进食组转入限时进食组的小鼠原本增加的体重也有一定程度的减轻。
“Time-restricted eating didn’t just prevent but also reversed obesity,” says Satchidananda Panda, an associate professor at the Salk Institute who oversaw the studies. “That was exciting to see.” Mice that consumed regular kibble in fixed time periods also had less body fat than those that ate the same food whenever they chose.
“限时饮食不仅可以预防肥胖,还可以逆转肥胖,”该研究的负责人,索尔克生物研究所的副教授萨特旦安达·潘达(Satchidananda Panda)说,“这样的发现真令人兴奋。”此外,与在一天的任何时间都可以食用鼠粮的小鼠相比,每天只能在固定时段食用相同食物的小鼠的体脂肪量也较低。
Precisely how a time-based eating pattern staved off weight gain and illness is not fully understood, but Dr. Panda and his colleagues believe that the time at which food is eaten influences a body’s internal clock. “Meal times have more effect on circadian rhythm than dark and light cycles,” Dr. Panda says. And circadian rhythm in turn affects the function of many genes in the body that are known to involve metabolism.
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