这项研究的作者萨拉·E·米勒教授评论说:“在这项研究中,我们已经表明,无毛区域的皮肤自然会产生一种阻止WNT发挥作用的抑制剂。”
Millar, who is a professor in dermatology at the University of Pennsylvania School of Medicine, continued: "We know that WNT signaling is critical for the development of hair follicles; blocking it causes hairless skin, and switching it on causes formation of more hair."
米勒是宾夕法尼亚大学医学院皮肤学教授,他接着说:“我们知道WNT信号对毛囊的发育至关重要;阻断它会导致无毛的皮肤,而开启它会导致更多毛发的形成。”
For their study, the researchers analyzed mouse skin similar to that on a human wrist. Their work showed the protein DKK2 was expressed highly in this part of the mammal compared to hairy areas.
在他们的研究中,研究人员分析了老鼠与人类手腕相似的皮肤。他们的工作表明,与毛发区相比,这部分哺乳动物体内的DKK2蛋白表达量较高。
As with mice, humans don't grow hair in their wrist area, whereas other mammals, like rabbits and polar bears, do, the authors highlighted. When they compared DKK2 expression in mouse wrist skin with rabbit, they found it in lower levels in the latter.
研究人员强调,与老鼠一样,人类手腕部位的毛发不会生长,而兔子和北极熊等其他哺乳动物会。他们将小鼠腕部皮肤的DKK2表达与兔腕部皮肤的DKK2表达进行比较,发现兔腕部皮肤的DKK2表达较低。
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