Since the 1990s, couples undergoing IVF have been able to screen their embryos for mutations in single genes that cause serious diseases such as cystic fibrosis, as well as conditions like Down’s syndrome, caused by chromosome abnormalities.
自上世纪90年代以来,接受试管受精的夫妇已经能够对他们的胚胎进行筛选,以发现单个基因的突变,这些突变会导致严重的疾病,比如囊性纤维化,以及染色体异常导致的唐氏综合征等。
chromosome ['krəʊməsəʊm]:n.染色体
Many other traits, including height, physical appearance, intelligence and disease susceptibility, are known to be partly heritable. But because the genetic component is spread thinly over hundreds or even thousands of DNA regions, it has previously been impossible to screen for these traits.
许多其他特征,包括身高、外貌、智力和疾病易感性,都被认为是部分遗传的。但由于遗传组分稀疏地分散在数百甚至数千个DNA区域,以前不可能对这些特征进行筛选。
In the past decade, as vast genetic databases have been established, this picture has changed. Through analyzing many genes, each making a tiny contribution, it has been possible to calculate what are called polygenic risk scores, which give a person’s likelihood of getting a particular disease or having a certain trait.
在过去的十年里,随着大量基因数据库的建立,这种情况已经发生了改变。通过分析大量基因,每个基因都做出了微小的贡献,就有可能计算出所谓的多基因风险评分,即一个人患某种特定疾病或具有某种特征的可能性。
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2020-09-15
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