To evaluate the potential of EcN's evolution after it's swallowed, the research team used mice specially bred to be completely germ free.

为了评估EcN被吞食后的进化潜力，研究小组使用了完全无菌的特殊培育小鼠。

The test subjects were divided into four groups, each with a distinct gut microbiome. One was left completely sterile; the other three were given microbiomes reflecting various healthy and unhealthy states.

实验对象被分成四组，每组都有一个独特的肠道微生物群。一个完全无菌;另外三组给予反映各种健康和不健康状态的微生物群落。

Each group was dosed with EcN and then fed one of the following options - boring old lab mouse chow, a more natural mouse-friendly diet, a Westernised diet high in fats and sugars, and a Westernised diet that had some fibre added.

每一组都被给予EcN，然后喂食以下选项之一——乏味的一般实验鼠粮，更自然的老鼠友好型饮食，高脂肪和高糖的西式饮食，以及添加了一些纤维的西式饮食。

Five weeks later, the mice had their guts examined. Those happy little E. coli? It turns out they weren't all quite as friendly as they had been on their way in, especially in guts that had to deal with less than healthy diets.

五周后，检查了老鼠的肠道。还是那些快乐的小大肠杆菌？事实证明，它们并不都像刚来的时候那么友好，尤其是那些处于不得不应对不健康的饮食的肠道里的。

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