他们发现,睡眠小鼠脑中的突触比清醒小鼠的突触小18%。“整体而言,那个巨大的变化颇为惊人,”托诺尼博士说。
The second study was led by Graham H. Diering, a postdoctoral researcher at Johns Hopkins University. Dr. Diering and his colleagues set out to explore the synaptic homeostasis hypothesis by studying the proteins in mouse brains. “I’m really coming at it from this nuts-and-bolts place,” Dr. Diering said.
第二项研究由约翰霍普金斯大学博士后研究员格雷厄姆·H·迪林(Graham H. Diering)领导。迪林博士和同事们通过研究小鼠脑中的蛋白质来探索突触自稳态假说。“我真的是从这种细节出发来研究这个问题的,”迪林博士说。
In one experiment, Dr. Diering and his colleagues created a tiny window through which they could peer into mouse brains. Then he and his colleagues added a chemical that lit up a surface protein on brain synapses.
在一个实验中,迪林博士和同事们创建了一个小窗口,通过它可以窥看小鼠的大脑。然后,他和同事们在小鼠大脑内添加了一种化学物质,能够点亮脑突触上的表面蛋白。
Looking through the window, they found that the number of surface proteins dropped during sleep. That decline is what you would expect if the synapses were shrinking.
透过窗口,他们发现,在睡眠期间突触表面蛋白的数量下降。如果突触缩小,这种下降就应该会出现。
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